HI, I'm still curious about this since I have used pentob in my work before, I just remember that you get a good anaesthesia but it doesn't kill pain, so I always needed to add some additional to minimize pain while I was performing surgery, I didn't know you could use it to induce coma, I know though that it is used in animals to euthanize them, because of this overdose danger possibility it became banned, but the dose is 3-4 times higher for euthanasia than for anaesthesia, I'm not sure which dose would be for coma here is a pubmed reference, I can't get the paper, but they may give more details,
1: Marshall GT, James RF, Landman MP, O'Neill PJ, Cotton BA, Hansen EN, Morris JA Jr, May AK. Pentobarbital coma for refractory intra-cranial hypertension after severe traumatic brain injury: mortality predictions and one-year outcomes in 55 patients. J Trauma. 2010 Aug;69(2):275-83. PubMed PMID: 20699736.
HI, I'm still curious about this since I have used pentob in my work before, I just remember that you get a good anaesthesia but it doesn't kill pain, so I always needed to add some additional to minimize pain while I was performing surgery, I didn't know you could use it to induce coma, I know though that it is used in animals to euthanize them, because of this overdose danger possibility it became banned, but the dose is 3-4 times higher for euthanasia than for anaesthesia, I'm not sure which dose would be for coma here is a pubmed reference, I can't get the paper, but they may give more details,
ReplyDelete1: Marshall GT, James RF, Landman MP, O'Neill PJ, Cotton BA, Hansen EN, Morris JA
Jr, May AK. Pentobarbital coma for refractory intra-cranial hypertension after
severe traumatic brain injury: mortality predictions and one-year outcomes in 55
patients. J Trauma. 2010 Aug;69(2):275-83. PubMed PMID: 20699736.